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  • A kidney biopsy study of early endemic nephropathy
    Ferluga, Dušan, 1934- ...
    The pathogenesis of endemic nephropathy (EN) is still unclear because of a limited number of kidney biopsy studies of earlier stages and lack of a biopsyfollow-up. Introducing the standard light, ... immunofluorescence and electron microscopy techniques, we analyzed kidney biopsy specimens of 50 patients who met the criteria for EN, and of 50 age-matched control subjects. Semiquantitative histomorphologic and statistical analysis confirmed a highly significant increase in the incidence and extent of global glomerular sclerosis, vascular sclerosis and hyalinosis, and tubular atrophy accompanied by interstitial fibrosis in EN patients in comparison with the age-matched control group, possibly suggesting intensified aging processes. Other peculiarhistomorphologic abnormalities of the incidence and extent were identified in EN patients only. The occurrence of multifocal double-outlined glomeruli, mucoid thickening of small blood vessels and transmural hyalinosis could be interpreted as a focal chronic thrombotic microangiopathy with endothelial cells as a key target. The similarity of etiologically still enigmatic EN with chronic cyclosporine, radiation, metal, ochratoxin A, and nephropathy induced by aristolochic acid was emphasized by comparing histomorpholh human and animal histology of etiologically confirmed renal diseases. Our original preliminary results suggested a significance of interstitial capillarosclerosis in EN. Viruses as tentative etiologic agents in EN appear to be much less probable than physicochemical agents. Our study resurfaces the hypothesis that aristolochic acid might be involved in the pathogenesis of EN.
    Vir: Endemic nephropathy in Croatia (Str. 43-72)
    Vrsta gradiva - članek, sestavni del
    Leto - 1996
    Jezik - angleški
    COBISS.SI-ID - 7741145

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