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  • Depressive disorder and antidepressants from an epigenetic point of view [Elektronski vir]
    Šalamon Arčan, Iris ; Kouter, Katarina, 1989- ; Videtič Paska, Alja, 1980-
    Depressive disorder is a complex, heterogeneous disease that affects approx- imately 280 million people worldwide. Environmental, genetic, and neurobio- logical factors contribute to the depressive ... state. Since the nervous system is susceptible to shifts in activity of epigenetic modifiers, these allow for significant plasticity and response to rapid changes in the environment. Among the most studied epigenetic modifications in depressive disorder is DNA methylation, with findings centered on the brain-derived neurotrophic factor gene, the glucocor- ticoid receptor gene, and the serotonin transporter gene. In order to identify biomarkers that would be useful in clinical settings, for diagnosis and for treatment response, further research on antidepressants and alterations they cause in the epigenetic landscape throughout the genome is needed. Studies on cornerstone antidepressants, such as selective serotonin reuptake inhibitors, selective serotonin and norepinephrine reuptake inhibitors, norepinephrine, and dopamine reuptake inhibitors and their effects on depressive disorder are available, but systematic conclusions on their effects are still hard to draw due to the highly heterogeneous nature of the studies. In addition, two novel drugs, ketamine and esketamine, are being investigated particularly in association with treatment of resistant depression, which is one of the hot topics of contemporary research and the field of precision psychiatry.
    Source: World journal of psychiatry. - ISSN 2220-3206 (Vol. 12, no. 9, 2022, str. 1150-1168)
    Type of material - e-article ; adult, serious
    Publish date - 2022
    Language - english
    COBISS.SI-ID - 122214915

    Link(s):

    https://f6publishing.blob.core.windows.net/f9ed6846-d281-4783-87fc-76223b26dde7/WJP-12-1150.pdf
    Repository of the University of Ljubljana – RUL
    DOI

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