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  • Epigenetics in psychiatry [Elektronski vir] : beyond DNA methylation
    Kouter, Katarina, 1989- ; Šalamon Arčan, Iris ; Videtič Paska, Alja, 1980-
    The global burden of psychopathologies appears to be underestimated, since the global psychiatric disorder burden is exceeding other medical burdens. To be able to address this problem more ... effectively, we need to better understand the etiology of psychiatric disorders. One of the hallmarks of psychiatric disorders appears to be epigenetic dysregulation. While some epigenetic modifications (such as DNA methylation) are well known and studied, the roles of others have been investigated much less. DNA hydroxymethylation is a rarely studied epigenetic modification, which as well as being an intermediate stage in the DNA demethylation cycle is also an independent steady cell state involved in neuro- development and plasticity. In contrast to DNA methylation, DNA hydroxy- methylation appears to be related to an increase in gene expression and subsequent protein expression. Although no particular gene or genetic locus can be at this point linked to changes in DNA hydroxymethylation in psychiatric disorders, the epigenetic marks present good potential for biomarker identi- fication because the epigenetic landscape is a result of the interplay between genes and environment, which both influence the development of psychiatric disorders, and because hydoxymethylation changes are particularly enriched in the brain and in synapse-related genes.
    Source: World journal of psychiatry. - ISSN 2220-3206 (Vol. 13, no. 6, Jun. 2023, str. 319-330)
    Type of material - e-article ; adult, serious
    Publish date - 2023
    Language - english
    COBISS.SI-ID - 156170755

    Link(s):

    https://f6publishing.blob.core.windows.net/1243a3cb-ccda-47d3-89a3-4f21f9f0d0ab/WJP-13-319.pdf
    Repository of the University of Ljubljana – RUL
    DOI

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