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13.
TPF induction chemotherapy and concomitant irradiation with cisplatin and cetuximab in unresectable squamous cell carcinoma of the head and neck
Strojan, Primož ...
Background: To assess efficacy and toxicity of TPF induction chemotherapy and concomitant immunochemoradiotherapy with cetuximab and cisplatin in unresectable head and neck carcinoma.Methods: ...Treatment consisted of TPF induction chemotherapy (docetaxel 75 mg/m2 day 2; cisplatin, 75 mg/m2 day 2; and 5-fluorouracil 750 mg/m2 days 1-4; 4 cycles), followed by radiotherapy and concomitant weekly cetuximab, (250 mg/m2, after a loading dose of 400 mg/m2) and cisplatin (30 mg/m2).Results: 25/30 patients completed four cycles of induction chemotherapy. Six or more concomitant infusions of cisplatin and cetuximab were administered in 13/25 and 18/25 patients, respectively. The 2-year locoregional control, disease-free survival and overall survival were 47%, 47%, and 50%, respectively. Patients with grade 2 skin reaction to cetuximab had a superior outcome.Conclusion: The tested regimen was effective; however, cetuximab and low-dose cisplatin after induction TPF increased the treatment toxicity. A grade 2 skin rash correlated with improved efficacy.
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