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  • COVID-19 and cholesterol bi... (cover)
    COVID-19 and cholesterol biosynthesis [Elektronski vir] : towards innovative decision support systems
    Kočar, Eva, 1992- ...
    With COVID-19 becoming endemic, there is a continuing need to find biomarkers characterizing the disease and aiding in patient stratification. We studied the relation between COVID-19 and cholesterol ... biosynthesis by comparing 10 intermediates of cholesterol biosynthesis during the hospitalization of 164 patients (admission, disease deterioration, discharge) admitted to the University Medical Center of Ljubljana. The concentrations of zymosterol, 24-dehydrolathosterol, desmosterol, and zymostenol were significantly altered in COVID-19 patients. We further developed a predictive model for disease severity based on clinical parameters alone and their combination with a subset of sterols. Our machine learning models applying 8 clinical parameters predicted disease severity with excellent accuracy (AUC = 0.96), showing substantial improvement over current clinical risk scores. After including sterols, model performance remained better than COVID-GRAM. This is the first study to examine cholesterol biosynthesis during COVID-19 and shows that a subset of cholesterol-related sterols is associated with the severity of COVID-19.
    Source: iScience [Elektronski vir]. - ISSN 2589-0042 (Vol. 26, iss. 10, [article no.] 107799, 2023, str. 1-16)
    Type of material - e-article
    Publish date - 2023
    Language - english
    COBISS.SI-ID - 165467907

    Link(s):

    https://www.cell.com/action/showPdf?pii=S2589-0042%2823%2901876-X
    Repository of the University of Ljubljana – RUL
    DOI

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