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Antigen predstavitvene celice pri lupusnem glomerulonefritisu
Kojc, Nika
Introduction. Antigen presenting cells (APC) play a key role in immune response. They present antigens together with HLA-DR hystocompatibility molecules to the helper T lymphocytes, inducing their ...activation and mediatinginflammatory reaction. The aim of this study was to establish APC in glomeruli of normal kidney and of lupus glomerulonephritis (LGN). Systemic lupus erythematosus is an autoimmune disease in which the main pathogenetic mechanism is the deposition of immune complexes. However, in severe injury of the glomeruli, associated with capsular crescentic proliferation, cellular immune reaction mediated by APC could be involved. Material and methods. The retrospective study included 10 specimens of normal kidney, 10 of mild mesangial LGN, 10 of diffuse proliferative LGN without capsular crescents and 8 of diffuse proliferative GN with crescents in more than half of the involvedglomeruli. Immunoperoxidase techniques, streptavidin-biotin labelled and EnVision, were applied to demonstrate cells, positive for markers of APC (CDIa, 5100, HLA-DR), macrophages (CD68), lymphocytes T (CD3), cytotoxic lymphocytes T (CD8), lymphocytes B (CD79a), endothelial cells (CD31, F VIII), mesangial cells (smooth muscle actin) and podocytes (vimentin). The results were statistically assessed by analysis of variance with the Bonferoni test, Ttest, Pearson test, and Kruskal-Walliss test with Kolinogorov-Smirnov test. Results. CD1a+ cells were not demonstrated in the kidney. Rare S100+ cells were found in the interstitium of normal kidney. In the kidney of LGN patients, their density was increasing in correlation with the glomerular involvement. The HLA-DR molecule was expressed by endothelial cells and rare mesangial cells in the normal kidney. The comparison of HLA-DR with the macrophage marker CD68 showed that mesangial HLA-DR+ cells were macrophages. (Abstract truncated at 2000 characters.)
Type of material - research report
Publication and manufacture - Ljubljana : [N. Babič], 1999
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