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Spremembe v razmerju citokinov Th1 in Th2 pri bolnikih z avtoimunsko hipertirozo : magistrsko delo
Kocjan, Tomaž, 1966-
Graves' disease (GD) is characterised by hyperthyroidism, caused by stimulatory thyrotropin receptor (TSHR) antibodies. Recent research shows thatan important factor in the pathogenesis of autoimmune ...diseases is the change in the balance between Th1 cytokines, which promote cell mediated immunity, and Th2 cytokines, which promote humoral immunity. There are contradictory data about this balance , shift in GD. Our objective was to determine the Th1žTh2 cytokine balance shift in patients with newly diagnosed GD, when compared to the same balance in healthy controls. We isolated mononuclear cells (MNC) from the peripheral blood of healthy donors and from patients with newly diagnosed GD before treatment. The MNC were activated withionomycin or CD3 antibodies, both in combination with phorbol 12-myristate13-acetate (PMA). After 40-hour incubation, the concentrations of the cytokines produced (IFN-y, IL-4, IL-10, IL-12) in the culture supernatantswere measured by ELISA (Endogen, USA). After activation with ionomycin and PMA the MNC from patients with GD produced in cultures significantly less IL-12 and significantly more IL-10 and IL-4 than MNC from healthy controls. All calculated ratios of Th 1 against Th2 cytokines in MNC cultures from patients with GD were significantly lower than in MNC cultures from healthy controls. After activation with CD3 antibodies and PMA the MNC from patients with GD produced in cultures significantly less IL-12 and significantly more IL-10 than MNC from healthy controls. All calculated ratiosof Th1 against Th2 cytokines in MNC cultures from patients with GD, except the ratio IFN-yžIL-4, were significantly lower than in MNC cultures from healthy controls. (Abstract truncated at 2000 characters).
Type of material - master's thesis
Publication and manufacture - Ljubljana : [T. Kocjan], 1999
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