Impact of metformin and rosiglitazone treatment on GLUT4 mRNA expression in women with polycystic ovary syndrome
Jensterle Sever, Mojca, dr. med. ...
The insulin resistant state of the polycystic ovary syndrome (PCOS) was found to be associated with a decreased glucose transporter GLUT4 expression in the insulin target tissues. This study was ...performed to explore whether the well-known clinical, hormonal and metabolic efficacy of metformin or rosiglitazone treatment is reflected in the modulation of adipocyte GLUT 4 mRNA expression in patients with PCOS. MethodsČ We enrolled 35 women with PCOS. They received either metformin or rosiglitazone for 6 months. History, blood samples for measurement of androgens and subcutaneous adipose tissue samples were taken at baseline and at endpoint. Quantification of GLUT4 mRNA expression in adipose tissue was performed by real-time quantitative PCR. Homeostasis model assessment (HOMAIR) score calculation was applied as a measure for insulin resistance (IR). Results: GLUT 4 mRNA expression in adipose tissue increased significantly in both groups (p<0.001). The increase was more pronounced in the rosiglitazone (ROSI) group (p=0.040). There was a statistically significant improvement of HOMAIR in both groups (p=0.008). After treatment, frequencies of menstrual bleeding were significantly higher (p<0.001) and serum total testosterone levels significantly lower in both groups (p=0.001). ConclusionsČ A six-month therapy with insulin sensitizers resulted in marked improvement in adipose tissue GLUT 4 mRNA expression in PCOS patients, rosiglitazone being more effective as compared to metformin. The augmentation of the insulin signal transduction was accompanied by a significant improvement of HOMAIR , menstrual pattern and androgen profile.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Impact factor
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
PDF
