Cumulative input function method for linear compartmental models and spectral analysis in PET
Simončič, Urban, 1981- ; Jeraj, Robert
Compartmental modeling and spectral analysis are often used for tracer kineticmodeling in positron emission tomography (PET). The concentrations in kinetic equations are usually considered to be ...instantaneous, whereas PET dataare inherently integrated over time, which leads to uncertainties in the results. A new formalism for kinetic analysis that uses cumulative tracer concentrations and avoids approximating the image-derived input function and PET measurements with midframe instantanous values was developed. We assessed the improvements of the new formalism over the midframe approximation methods for three commonly used radiopharmaceuticalsČ š11Cđraclopride, 2Ž-deoxy-2Ž-š18Fđfluoro-D-glucose (FDG), and 3Ž-deoxy-3Ž-š18Fđfluoro-thymidine(FLT). We found that improvements are case dependent and often not negligible. Improvements for determination of binding potential for š11Cđraclopride ranged from 5% to 25%. Improvements in estimation accuracy of FDG and FLT microparameters ranged up to 25%. On the other hand, estimation of macroparameter Ki=K1k3ž(k2+k3) for FDG or FLT did not show significant benefit with the new methodč only modest improvement up to 2% was observed. Assessment of the benefits of using new method is far frombeing exhaustive, but possibly significant improvement was demonstrated. Therefore, we consider the proposed algorithm a necessary component of any kinetic analysis software.
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