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  • Imaging for Assessment of Radiation-Induced Normal Tissue Effects
    Jeraj, Robert ...
    Imaging can provide quantitative assessment of radiation-induced normal tissueeffects. Identifying an early sign of normal tissue damage with imaging would have the potential to predict organ ... dysfunction, thereby allowing reoptimization of treatment strategies based on individual patientsć risks andbenefits. Early detection with noninvasive imaging may enable interventionsto mitigate therapy-associated injury before its clinical manifestation. Furthermore, successive imaging may provide an objective assessment of the impact of such mitigation therapies. However, many problems make application of imaging to normal tissue assessment challenging, and further work is required to establish imaging biomarkers as surrogate endpoints of clinical outcome. The performance of clinical trials in which normal tissue injury is a clearly defined endpoint would greatly aid in realization of these goals.
    Source: International journal of radiation oncology, biology, physics. - ISSN 0360-3016 (Suppl. 1, Iss. 3, Vol. 76, str. S140-S144)
    Type of material - article, component part
    Publish date - 2010
    Language - english
    COBISS.SI-ID - 24433191

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