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Perfect phylogenies via the minimum uncovering branching problem [Elektronski vir] : efficiently solvable casesBaghirova, Narmina ; Galby, Esther ; Milanič, Martin, 1980-In this paper, we present new efficiently solvable cases of the Minimum Uncovering Branching problem, an optimization problem with applications in cancer genomics introduced by Hujdurovi´c, Husi´c, ... Milaniˇc, Rizzi, and Tomescu in 2018. The problem involves a family of finite sets, and the goal is to map each non-maximal set to exactly one set that contains it, minimizing the sum of uncovered elements across all sets in the family. Hujdurovi´c et al. formulated the problem in terms of branchings of the digraph formed by the proper set inclusion relation on the input sets and studied the problem complexity based on properties of the corresponding partially ordered set, in particular, with respect to its height and width, defined respectively as the maximum cardinality of a chain and an antichain. They showed that the problem is APX-complete for instances of bounded height and that a constant-factor approximation algorithm exists for instances of bounded width, but left the exact complexity for bounded-width instances open. In this paper, we answer this question by proving that the problem is solvable in polynomial time. We derive this result by examining the structural properties of optimal solutions and reducing the problem to computing maximum matchings in bipartite graphs and maximum weight antichains in partially ordered sets. We also introduce a new polynomially computable lower bound and identify another condition for polynomial-time solvability.Source: IEEE transactions on computational biology and bioinformatics [Elektronski vir]. - ISSN 2998-4165 (Vol. 22, iss. 5, Sep./Oct. 2025, str. 2043-2056)Type of material - e-article ; adult, seriousPublish date - 2025Language - englishCOBISS.SI-ID - 252020739
Author
Baghirova, Narmina |
Galby, Esther |
Milanič, Martin, 1980-
Topics
popolna filogenija |
vejitev |
delno urejena množica |
antiveriga |
širina |
perfect phylogeny |
branching |
partially ordered set |
antichain |
width
| Author | Baghirova, Narmina ; Galby, Esther ; Milanič, Martin, 1980- |
| Title | Perfect phylogenies via the minimum uncovering branching problem [Elektronski vir] : efficiently solvable cases |
| Publication date | |
| COBISS.SI-ID | 252020739 |
| Publication version in repository | Unidentified |
| Publication licence | Unidentified |
| Embargo | Unidentified |
Project(s) from which the publication was funded
| Title | Acronym | Project ID | Funder |
|---|---|---|---|
| Infrastrukturna skupina Univerze na Primorskem | I0-0035-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
| Algebra, diskretna matematika, verjetnostni račun in teorija iger | P1-0285-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
| Grupe, poseti, in kompleksi | J1-3003-2021 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
| Drevesno neodvisnostno število grafov | J1-4008-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
| Določeni kombinatorični objekti v spektralni domeni - križiščna analiza | J1-4084-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
| “Linearne kode preko posebnih razredov funkcij - relacije in načrtovanje | J1-60012-2025 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
| Onkraj redkosti: razredi grafov in širinski parametri | N1-0370-2024 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
| CogniCom | 0013103 |
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| Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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| Baghirova, Narmina | ![]() |
| Galby, Esther | ![]() |
| Milanič, Martin, 1980- | 30211 |
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