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  • Cross-affinity of peptide ligands selected from phage display library against pancreatic phospholipase A2 and ammodytoxin C
    Gaser, Dominik ...
    Two phage-displayed random peptide libraries were screened for ligands with potential inhibitory activity against pancreatic phospolipase A2 or ammodytoxin C (neurotoxin found in the venom glands of ... Vipera ammodytes ammodytes). The interaction of selected peptides with pancreatic phospholipase A2 and ammodytoxin C was confirmed with surface plasmon resonance and phage ELISA assays. Interestingly, peptides showed equal affinity to both proteins, regardless which of the two proteins was used as a target in the selection procedure. Despite pronounced affinity, none of the synthetic peptides inhibited enzyme targets in vitro at the concentrations below 167 [micro]M.
    Source: Acta chimica slovenica. - ISSN 1318-0207 (Vol. 56, no. 3, 2009, str. 712-717)
    Type of material - article, component part
    Publish date - 2009
    Language - english
    COBISS.SI-ID - 2656113

source: Acta chimica slovenica. - ISSN 1318-0207 (Vol. 56, no. 3, 2009, str. 712-717)
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