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Nanotelesa : alternativa klasičnim monoklonskim protitelesom = Nanobodies : an alternative to conventional monoclonal antibodiesBabič, Davor, kemija ; Čurin-Šerbec, Vladka ; Jovchevska, IvanaTežkoverižna protitelesa, prvič odkrita pri kamelidih leta 1989, predstavljajo nekonvencionalno obliko protiteles, sestavljeno izključno iz težkih verig in brez lahkih verig, značilnih za klasična ... protitelesa. Njihova posamezna variabilna domena, imenovana nanotelo ima ključne prednosti pred konvencionalnimi protitelesi: stabilnost, manjša velikost, visoka topnost v vodi, boljše prehajanje v tkiva in enostavna proizvodnja v rekombinantnih sistemih. Nanotelesa raziskujejo predvsem na področju diagnostike, kjer se uporabljajo v tehnikah, kot so pozitronska emisijska tomografija s hkratno računalniško tomografijo, biosenzorji in imunokromatografski testi. V terapevtske namene jih razvijajo za zdravljenje raka ter infekcijskih in avtoimunskih bolezni. Od prve odobritve kaplacizumaba leta 2018 so bila odobrena še tri zdravila na osnovi nanoteles, kar potrjuje njihov vse večji pomen v translacijski in klinični medicini.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 77, št. 1, mar. 2026, str. 63-73)Type of material - article, component part ; adult, seriousPublish date - 2026Language - slovenianCOBISS.SI-ID - 273357059
Author
Babič, Davor, kemija |
Čurin-Šerbec, Vladka |
Jovchevska, Ivana
Topics
kaplacizumab |
monoklonska protitelesa |
nanotelesa |
PET/CT |
rak (medicina) |
caplacizumab |
monoclonal antibodies |
nanobodies |
cancer |
PET/CT
| Author | Babič, Davor, kemija ; Čurin-Šerbec, Vladka ; Jovchevska, Ivana |
| Title | Nanotelesa : alternativa klasičnim monoklonskim protitelesom = Nanobodies : an alternative to conventional monoclonal antibodies |
| Publication date | |
| COBISS.SI-ID | 273357059 |
| Publication version in repository | Unidentified |
| Publication licence | Unidentified |
| Embargo | Unidentified |
Project(s) from which the publication was funded
| Title | Acronym | Project ID | Funder |
|---|---|---|---|
| Funkcijska genomika in biotehnologija za zdravje | P1-0390-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 77, št. 1, mar. 2026, str. 63-73)
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DRS, in which the journal is indexed
| Database name | Field | Year |
|---|
| Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
|---|---|
| Babič, Davor, kemija | ![]() |
| Čurin-Šerbec, Vladka | 05236 |
| Jovchevska, Ivana | 38279 |
Source: Personal bibliographies
and: SICRIS
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