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  • Kombinirano zdravljenje neovaskularne oblike starostne degeneracije makule s fotodinamičnim zdravljenjem in ranibizumabom - 2 letno poročilo = Combination therapy for neovascular form of agerelated macular degeneration with photodynamic therapy and ranizumab - 2 year report
    Kraut, Aleksandra, 1947-2025 ...
    Background: Evaluate the efficacy and safety of photodynamic therapy (PDT) combined with intravitreal injections of ranibizumab in choroidal neovascularisation (CNV) secondary to agerelated macular ... degeneration (AMD). Methods: Prospective, noncomparative, interventional case series of 10 patients. Patients were treated at baseline with verteporfin PDT, followed by intravitreal injection of 0.3mg ranibizumab one hour later. Repeated monthly ranibizumab injections were given for three months, followed by further monthly doses, if necessary, depending on the findings of the best corrected visual acuity (BCVA), and fluorescein angiography (FA). FA was conducted after3, 6 and 12 months, and optical coherent tomography (OCT) in the last 18 months of the study. Efficacy was evaluated by the changes in BCVA using EarlyTreatment Diabetic Retinopathy Study (ETDRS) charts, by anatomic outcomeson FA, and by number of retreatments. Safety was assessed by ophthalmic examinations, monitoring adverse events and vital signs. Results: Baseline BVCA ranged from 34-71 letters (mean 57.2). FA types CNV appeared as predominantly classic in 2, minimally classic in 3, occult without classic in 5 patients. Retinochoroidal anastomosis (RCA) was found in 4 patients. After one and two years mean BVCA was 70 and 66.4; mean gain was 12.8 and 9.2 letters respectively. FA outcomes after 6 months showed that all leasions weresmaller, with CNV shrinkage while RCA disappeared. The number of ranibizumab injections per patient was 4-9 in year one and 0-5 in year two. There were no serious side effects. Conclusions: PDT combined with ranibizumabinjections is a safe, effective, and appropriate therapy for neovascular forms of ARMD. Anatomic and visual outcomes are good and less retreatments are needed. Definitive significance of the therapy will be known after conclusion of ongoing large multicentric clinical trials.
    Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 79, suppl. , dec. 2010, str. I-39 - I-45)
    Type of material - article, component part
    Publish date - 2010
    Language - slovenian
    COBISS.SI-ID - 27812057

    Link(s):

    http://szd.si/user_files/vsebina/Zdravniski_Vestnik/2010/suplement/i-39-45.pdf
    Digitalna knjižnica Slovenije - dLib.si

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