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Subtherapeutic, low-dose fluvastatin improves functional and morphological arterial wall properties in apparently healthy, middle-aged males - a pilot study
Lunder, Mojca, dr. med. ...
OBJECTIVE: Early arterial wall changes are already present in the apparently healthy, middle-aged population and continuously progress with age. The aim ofour study was to investigate whether 30 days ...low-dose fluvastatin treatment could improve and reverse these arterial changes that are primarily associatedwith ageing, in otherwise healthy middle-aged males. METHODS: In a double blind, randomized study, 50 middle-aged males received either placebo or fluvastatin (10mg) for 30 days. Brachial artery flow-mediated dilation (FMD), pulse wave velocity (PWV) and beta-stiffness of the common carotid artery were measured on the 1st, 14th and 30th day of the study using an Alokainstrument by integrated eTracking. RESULTS: In 77% of subjects, impairedendothelial function was revealed at inclusion in the study. All the parameters were improved already after 14 days, and after 30 days of treatmentFMD improved by 91.5 15.6%, while PWV and ß-stiffness improved by 6.2 1.1% and 10.7 1.5%, respectively (all P<0.001). After therapy discontinuation, the beneficial effects progressively decreased, but were still detectable after 5 months. During the study the lipid profile remained unchanged, thus the beneficial effects obtained were attributed to the pleiotropic effects of fluvastatin. CONCLUSIONS: We found that subtherapeutic low-dose fluvastatin (10mg daily; 30 days) considerably improves and reverses early functional and morphological arterial wall impairments that are present in apparently healthy, middle-aged males. It might be supposed that such a newand original approach could be valuable in cardiovascular prevention.
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