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  • Raziskava o doseganju ciljne srčne frekvence, protiishemične in protianginozne učinkovitosti ter prenašanja zdravila ivabradin (ProCoralan) pri bolnikih s stabilno angino pektoris - PROTECT = Study on reaching the target heart rate, antiischemic and antianginal effectiveness of ivabradin (Procorolan) in patients with stable angina pectoris - PROTECT
    Poles, Janez ...
    Ischemic heart disease (IHD) is the main reason for become ill and death also in slovenia. Heart rate has an important role in disease development because heart rate and blood pressure are an ... indicator of heart burden. The guidelinesrecommend heart rate between 50 and 60 beat per minute forthe patients with angina pectoris. The authors were interested for antiischemic and antianginostic effect of a new drug ivabradin (Procoralan), its influence on physical performance, well-being and possible side-effects. They included 110 out patients with stable angina pectoris and regular sinus rhitmus in the research. All patients had clinical examination, ECG recording and blood pressure measurement. They made also 6 minute walk test and answered on surveyabout well-being. They started to take ivabradine 5 mg twice per day. After one month followed an control examination. The results showed significant reduction of heart rate, reducing of angina pectoris attacks, smaller consumption of short acting nitrates, improvement of physical performance and better wel-being. There were no side effects. They establishedthat ivabradin is good antiischemic and antianginostic drug and it significant improves physical performance and quality of life. It is reasonably to combine it with other drugs which we use for threating IHD. In patinets with IHD, stable angina pectoris and asthma ivabradine is an decisiontherapy.
    Source: Slovenska kardiologija : znanstveno strokovna revija za področje srčno-žilne medicine. - ISSN 1581-8543 (Letn. 8, št. 1/2, maj 2011, str. 8-12)
    Type of material - article, component part
    Publish date - 2011
    Language - slovenian
    COBISS.SI-ID - 28683993

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