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CTSS activation coexists with CD40 activation in human atheroma : evidence fromplasma mRNA analysis
Černe, Darko ...
Objectives: By the analysis of plasma mRNA levels, we tested the hypothesis that, in human atheroma, CTSS activation coexists with activation of CD40. Design and methods: mRNAs were isolated from ...plasma of patients with coronary atherosclerosis and quantified by real-time RT-PCR. Results: CTSS mRNA levels correlated with CD40 mRNA levels, independently of observed traditional risk factors for atherosclerosis and pharmacological treatment. Conclusions: Our results suggest that CTSS mediated atherogenesis may be associated with a CD40 mediated inflammatory and immune response. Further invasive atheroma analysis is reasonable.
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