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  • VEP characteristics in children with achiasmia, in comparison to albino and healthy children
    Brecelj, Jelka ...
    Achiasmia is a rare disorder of visual pathway maldevelopment that can show diverse clinical and magnetic resonance imaging spectra. The aim of this studywas to define the characteristics of visual ... evoked potentials (VEPs) thatdifferentiate abnormal optic-nerve-fibre decussation in children with achiasmia versus children with albinism and healthy children. In four childrenwith achiasmia, the following VEP characteristics were studied and compared to children with ocular albinism and with healthy control children: (a) flash and pattern onset VEP interhemispheric asymmetry; (b) flash N2, P2 and onset C1 amplitudes and latencies; (c) interocular polarity differences ininterhemisphere potentials; and (d) chiasm coefficients (CCs). In the children with achiasmia, VEPs were related to an absence of or reduced optic-nerve-fibre decussation at the chiasm and showed: ipsilateral asymmetry,significantly higher VEP amplitudes over the ipsilateral hemisphere (p < 0.05), interocular inverse polarity and negative CC. Other VEP features (uncrossed asymmetry and positive CC) were also seen if additional visual pathway maldevelopment (such as severe optic nerve hypoplasia and/or absence of the optic tractus on one side) were associated with achiasmia. In the children with albinism, the VEPs were related to excess optic-nerve-fibre decussation at the chiasm and showed: contralateral asymmetry, significantly higher VEP amplitudes over the contralateral hemisphere (p < 0.001), interocular inverse polarity and negative CC. In achiasmia and albinism, the VEPs to flash stimulation were more robust and more clearly distinguished between the conditions compared with the VEPs to pattern onset stimulation. VEPs in achiasmia are associated with absent or reduced optic-nerve-fibre decussation, where ipsilateral interhemispheric asymmetry is associated with interocular inverse polarity and a negative CC.
    Source: Documenta ophthalmologica. - ISSN 0012-4486 (Vol. 124, no. 2, 2012, str. 109-123)
    Type of material - article, component part
    Publish date - 2012
    Language - english
    COBISS.SI-ID - 29828313
    DOI

source: Documenta ophthalmologica. - ISSN 0012-4486 (Vol. 124, no. 2, 2012, str. 109-123)
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