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  • International cohort study of 73 anti-Ku-positive patients [Elektronski vir] : association of p70/p80 anti-Ku antibodies with joint/bone features and differentiation of disease populations by using principal-components analysis
    Lakota, Katja ...
    Introduction: An international cohort study of 73 anti-Ku-positive patients with different connective tissue diseases was conducted to differentiate the anti-Ku-positive populations of patients based ... on their autoantibody profile and clinical signs/symptoms and to establish possible correlations between antibodies against Ku p70 and Ku p80 with autoimmune diseases. Methods: Sera of anti-Ku-positive patients were collected from six European centers and wereall secondarily tested (in the reference center); 73 were confirmed as positive. Anti-Ku antibodies were detected with counter-immunoelectrophoresis (CIE), line immunoassay (LIA), and immunoblot analyses. All clinical and laboratory data were follow-up cumulative data, except for anti-Ku antibodies.Statistical analyses were performed by using R (V 2.12.1). The Fisher Exact test was used to evaluate the association between anti-Ku antibodies and diagnosis, gender, clinical signs, and other observed antibodies. The P values were adjusted for multiple testing. Separation of disease populations based on the presence of antibodies and clinical signs wasinvestigated by principal-components analysis, which was performed by usingthr// R's prcomp function with standard parameters. Results: A 16% higherprevalence of anti-Ku p70 was found over anti-Ku p80 antibodies. In 41 (57%) patients, a combination of both was detected. Five (7%) patients, who were CIE and/or LIA anti-Ku positive, were negative for both subsets, as detected with the immunoblot; 31% of the patients had undifferentiated connective tissue disease (UCTD); 29% had systemic sclerosis (SSc); 18% had systemic lupus erythematosus (SLE); 11% had rheumatoid arthritis; 7% had polymyositis; and 3% had Sjogren syndrome. (Abs. trunc. at 2000 ch.)
    Source: Arthritis research & therapy [Elektronski vir]. - ISSN 1478-6362 (Vol. 14, iss. 1, 2012)
    Type of material - e-article ; adult, serious
    Publish date - 2012
    Language - english
    COBISS.SI-ID - 29876185

    Link(s):

    http://arthritis-research.com/content/14/1/R2
    DOI

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