Diagnostic value of cytokines and chemokines in Lyme neuroborreliosis
Cerar Kišek, Tjaša, 1980- ...
The aim of the present study was to assess concentrations of different cytokines and chemokines in serum and CSF of patients with Lyme neuroborreliosis, and to identify possible marker(s) that would ...enable distinction between clinically evident and suspected Lyme neuroborreliosis as well as between Lyme neuroborreliosis and tick-borne encephalitis (TBE). Our additional interest was to evaluate relationship between cytokine/chemokine concentrations and B. burgdorferi sensu lato isolation from CSF as well as intrathecal synthesis of specific borrelial antibodies.We found that higher concentrations of CXCL 13 and lower concentrations of IL-10 in sera were associated with higher odds for clinically evident Lyme neuroborreliosis in comparison to suspected Lyme neuroborreliosis as well as to TBE. CSF concentrations of IL-2, IL-5, IL-6, IL-10 and CXCL13 in the CSF were higher in patients with evident Lyme neuroborreliosis in comparison to those with suspected Lyme neuroborreliosis. Comparison of CSF cytokines and chemokines levels in patients with and without intrathecal synthesis of specific borrelial antibodies revealed that CXCL13 CSF concentration is significantly associated with intrathecal synthesis of borrelial antibodies. Comparison of cytokine and chemokine CSF concentrations in patients with clinically evident Lyme neuroborreliosis according to CSF culture result revealed that higher concentrations of IFN- were associated with lower odds for borrelia isolation.Although several differences in serum and CSF concentrations of various cytokines and chemokines between the groups were found, the distinctive power of the majority of these findings was low. Further research on well-defined groups of patients is needed to appraise their potential diagnostic usefulness.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Impact factor
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
PDF
