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  • TRPV1 and endocannabinoids [Elektronski vir] : emerging molecular signals that modulate mammalian vision
    Ryskamp, Daniel A. ...
    Transient Receptor Potential Vanillo id 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity an d endogenous metabolites of polyunsaturated fatty acids. While ... originally repo rted to serve as a pain and heat detector in the peripheral nervous system, TRPV1 has been implicated in th e modulation of blood flow and osmoregulation but also neurotra nsmission, postsynaptic ne uronal excitability and synaptic plasticity within the central nervous system. In a ddition to its central role in nociception, evidence is accumulating that TRPV1 contributes to stimulus transduction and/or processing in other sensory m odalities, including thermosensation, mechanotransduction and vision. For example, TRPV1, in conjunction with intrinsic cannabinoid signaling, might cont ribute to retinal ganglion ce ll (RGC) axonal transport and excitability, cytokine release from microglial cells and regulation of retinal vasculature. While excessive TRPV1 activity was pr oposed to induce RGC excitotoxicity physiological TRPV1 activity might serve a ne uroprotective function within the complex context of retinal endocannabi noid signaling. In this review we evaluate the current evidence for localization and function of TR PV1 channels within the mammalian retina and explore the potential inte raction of this intriguing noc iceptor with endogenous agonists and modulators.
    Source: Cells [Elektronski vir]. - ISSN 2073-4409 (Vol. 3, iss. 3, Sep . 2014, str. 914-938)
    Type of material - e-article ; adult, serious
    Publish date - 2014
    Language - english
    COBISS.SI-ID - 31835609

    Link(s):

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197638/pdf/cells-03-00914.pdf
    DOI

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