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  • Genetic polymorphisms in dopaminergic system and treatment-resistant schizophrenia
    Terzić, Tea ...
    Background: Dopaminergic system plays an important role in ant ipsychotic response. Func tional single nucleotide polymorphisms (SNPs) can change dopamine receptor expression or dopamine disposition ... and thus influence response to anti- psychotic treatment. Subjects and methods: 138 schizophrenia patients were stratified in the treatment-resistant and tr eatment-responsive group. Control group consisted of 94 healthy blood donors. All subjects we re genotyped for the following SNPs: DRD1 (rs4532, rs5326), DRD2 (rs1801028, rs1799732), DRD3 (rs6280) and COMT (rs165815, rs4680). Association between the genotypes and clinical symptoms were tested using ANCOVA with cu rrent antipsychotic dose as a confounder. Di fferences in allele frequencies between treatment-responsive and treatment-resistant schizophrenic patients were assessed using % 2 tests. Results: No statistically significant associations were observed between any of the inves tigated genotypes and c linical scores and occurrence of the treatment- resistant schizophrenia. Conclusions: Genetic variability in dopaminergic syst em does not have a major role in clinical symptoms and occurrence of treatment-resistant schizophren ia among Slovenian patients.
    Source: Psychiatria Danubina : an international multidisciplinary journal = eine internationale Zeitschrift. - ISSN 0353-5053 (Vol. 28, no. 2, Jun. 2016, str. 127-131)
    Type of material - article, component part ; adult, serious
    Publish date - 2016
    Language - english
    COBISS.SI-ID - 32741593

    Link(s):

    http://www.hdbp.org/psychiatria_danubina/pdf/dnb_vol28_no2/dnb_vol28_no2_127.pdf

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