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  • Berberine in cardiovascular and metabolic diseases [Elektronski vir] : from mechanisms to therapeutics
    Feng, Xiaojun ...
    Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide, underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is an eminent component of ... traditional Chinese and Ayurvedic medicine for more than 2000 years. Recently, BBR has attracted much interest for its pharmacological actions in treating and/or managing CVMD. Recent discoveries of basic, translational and clinical studies have identified many novel molecular targets of BBR (such as AMPK, SIRT1, LDLR, PCSK9, and PTP1B) and provided novel evidences supporting the promising therapeutic potential of BBR to combat CVMD. Thus, this review provides a timely overview of the pharmacological properties and therapeutic application of BBR in CVMD, and underlines recent pharmacological advances which validate BBR as a promising lead drug against CVMD.
    Source: Theranostics [Elektronski vir]. - ISSN 1838-7640 (Vol. 9, no. 7, 2019, str. 1923-1951)
    Type of material - e-article
    Publish date - 2019
    Language - english
    COBISS.SI-ID - 34256857

    Link(s):

    http://www.thno.org/v09p1923.htm
    DOI

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