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How could we slow or reverse the human aging process and extend the healthy life span with heterochronous autologous hematopoietic stem cell transplantation
Rožman, Primož, 1954-
The senescence of the immune system contributes considerably to the age-related diseases that are the main causes of death after the age of 65. The heterochronous autologous hematopoietic stem cell ...transplantation, where healthy autologous bone marrow stem cells are collected from donors while young, cryopreserved for a long period, and reinfused at a later time, has been recently proposed as a method for the prevention of immune senescence and delay of the aging process. After heterochronous reinfusion and homing, these young hematopoietic stem cells home in the stem cell niches, where they participate in normal hemato- and immunopoiesis, and improve several immune functions by expanding the immune- and hematopoietic cell repertoires. Although some animal studies confirmed the feasibility of this procedure and extended the longevity of the treated animals, translation to human medicine is much more complex. The question remains whether the heterochronous autologous hematopoietic stem cell transplantation will in fact prevent or mitigate age-related immune defects in a manner that will also extend the healthy life span in humans. In this review, we discuss translational aspects of this procedure and describe further research needed to use this heterochronous methodology.
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