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Internalization and accumulation in dendritic cells of a small pH-activatable glycomimetic fluorescent probe as revealed by spectral detection
Arsov, Zoran ...
DC-SIGN, an antigen-uptake receptor in dendritic cells (DCs), has a clear role in the immune response but can, conversely, also facilitate infection by providing entry of pathogens to DCs. The key ...action in both processes is internalization to acidic endosomes and lysosomes. Molecular probes that bind to DC-SIGN could thus provide a useful tool to study internalization and, at the same time, constitute potential antagonists against pathogens. So far, only large molecules have been used to directly observe DC-SIGN mediated internalization into DCs. To fill this gap, we designed and synthesized an appropriate small glycomimetic probe. Two particular properties of the probe were exploited: activation in a low-pH environment and an aggregation-induced spectral shift. Our results indicate that small glycomimetic molecules could compete with antigen/pathogen binding not only outside but also inside the DC, hence preventing harmful action of pathogens that are able to intrude the DC.
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