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  • Intravenous thrombolysis with recombinant tissue plasminogen activator (rt-PA) in acute lower limb ischaemia
    Flis, Vojko ...
    For various reasons some patients are unable to undergo intra-arterial thrombolysis for acute limb ischaemia. This interventional case series study prospectively evaluated the effect of thrombolytic ... treatment with 100 mg recombinant tissue plasminogen activator (rt-PA), administered intravenously, in patients with acute thrombosis of the lower limb arteries and onset of symptoms within 12 h prior to treatment. During a 3-year period (2007-2009), 18 of 86 patients satisfied the inclusion criteria and were included in the study (age range 65 - 80 years; 11 women). Complete and partial thrombolysis was observed in eight (44.4 %) and six (33.3 %) patients, respectively. All patients experienced clinical improvement. There were no amputations during the 36-month follow-up period and no haemorrhagic complications in the first 30 days post-treatment. Five patients died (27.8 %) during follow-up from unrelated causes. This small study demonstrated that thrombolytic treatment with intravenous rt-PA in selected patients with acute limb ischaemia is feasible.
    Source: Journal of international medical research. - ISSN 0300-0605 (Vol. 39, no. 3, 2011, str. 1107-1112)
    Type of material - article, component part ; adult, serious
    Publish date - 2011
    Language - english
    COBISS.SI-ID - 3998271

    Link(s):

    http://www.jimronline.net/content/full/2011/103/1677.pdf

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