A sensitive hydrophilic interaction liquid chromatography/electrospray ionization mass spectrometry (HILIC/ESI-MS/MS) method was developed for determination of selected aliphatic (i.e. malonic, ...succinic, glutaric, adipic,pimelic, suberic, azelaic, maleic, fumaric, glycolic and pyruvic acid),alicyclic (i.e. cis-pinonic and pinic acid) and aromatic (i.e. trimesic,phthalic acid and its isomers) carboxylic acids. Analytes were separated on an amide column using a gradient elution with a 10 mM constant ionic strength mobile phase containing acetonitrile and aqueous ammonium acetate buffer (pH 5.0). The influence of the buffer type, pH, polar modifier and temperature on analyte retention under HILIC was studied. Static sonication-assisted solvent extraction was optimized for sample preparation prior to analysis. The recoveries obtained were higher than 90% for most analytes. The method was proven to be sensitive with limits of detection ranged from 0.03 to 16.0 g/L in selected reaction monitoring mode (SRM). The repeatability and intermediate precision of the method, expressed as R.S.D (%)of the peak area ratio between analytes and their internal standards were generally lower than 5%. The method was successfully applied for determinationof the studied acids in samples of ambient aerosol particles. A big advantage of the new method is also its ability to detect and separate theisobaric compounds of the selected carboxylic acids. Our results demonstrate that the method is specific and sensitive for the determination ofa wider range of polar carboxylic acids at low concentrations in complex samples of aerosol particles.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Impact factor
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
