ALL libraries (COBIB.SI union bibliographic/catalogue database)
13.
Unique structural features of G-quadruplexes from the intron of the N-myc gene [Elektronski vir]
Plavec, Janez
Guanine-rich DNA regions have been shown to fold into four stranded structures called G-quadruplexes. Possible biological roles of G-quadruplexes have been implicated in many vital cell mechanisms. ...The potential of G-quadruplexes as therapeutic targets has been well established with evidenceof their prevalence in telomeres and gene promoters. NMR has been successful in determining 3D structures of several unique architectures of G-quadruplexes consisting of stacked G-quartets each formed by assembly of four Hoogsteen hydrogen-bonded guanine residues. Stability of G-quadruplexes depends on a number of stacked G-quartets as well as on length and sequence details of loops that connect guanines involved in G-quartets. Orientations of the loops are tightly related to strand directionality of a G-quadruplex and give rise to high heterogeneity of G-quadruplex folding topologies. The Myc family comprises c-myc, N-myc and L-myc proto-oncogenes, which encode proteins involved in mechanisms regulating cell growth, differentiation, proliferation and apoptosis. Expression of N-myc gene is restricted to specifi tissues during their development. Its deregulation is associated with neuronal tumors. Amplificatio and level of expression of N-myc oncogene has been studied due to their connection with pathophysiology of neuroblastoma cancer. An NMR structural study on oligonucleotide d[TAG3CG3AG3AG3A2], originating from the firs intron of the N-myc gene, demonstrated formation of G-quadruplex in K+ ion containing solution. The monomeric form of the oligonucleotide comprises three G-quartets that are bridged with three single nucleotide propeller-type loops. The monomeric formis involved in equilibrium with a dimeric form. The topology of dimeric G-quadruplex is characterized by consecutive stacking of six G-quartets. The four strands adopt parallel orientations and are connected with propeller-type loops. A link between the third and the fourth G-quartets consists of two adenine residues that are flippe out to facilitate consecutive stacking of six G-quartets.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Impact factor
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
