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  • Administration of Bifidobacterium breve decreases the production of TNF-[alfa] in children with celiac disease [Elektronski vir]
    Klemenak, Martina ...
    BACKGROUND: Increasing evidence suggests that not only genetics, but also environmental factors like gut microbiota dysbiosis play an important role in the pathogenesis of celiac disease (CD). AIM: ... The aim of our study was to investigate the effect of two probiotic strains Bifidobacterium breve BR03 and B. breve B632 on serum production of anti-inflammatory cytokine interleukin 10 (IL-10) and pro-inflammatory cytokine tumor necrosis factor alpha (TNF-[alfa]) in children with CD. METHODS: The study was a double-blinded, placebo-controlled trial that included 49 children with CD on gluten-free diet (GFD) randomized into two groups and 18 healthy children in the control group. The first group (24 children with CD) daily received B. breve BR03 and B632 (2 % 109 colony-forming units) and the second group (25 children with CD) received placebo for 3 months. RESULTS: TNF-[alfa] levels were significantly decreased in the first group after receiving B. breve for 3 months. On follow-up, 3 months after receiving probiotics, TNF-[alfa] levels increased again. Children with CD who were on GFD for less than 1 year showed similar baseline TNF-[alfa] levels as children who were on GFD for more than 1 year. IL-10 levels were in all groups of patients below detection level. CONCLUSIONS: Probiotic intervention with B. breve strains has shown a positive effect on decreasing the production of pro-inflammatory cytokine TNF-[alfa] in children with CD on GFD.
    Source: Digestive diseases and sciences [Elektronski vir]. - ISSN 1573-2568 (Vol. 60, iss. 11, Nov. 2015, str. 3386-3392)
    Type of material - e-article
    Publish date - 2015
    Language - english
    COBISS.SI-ID - 512528696

    Link(s):

    http://link.springer.com/article/10.1007%2Fs10620-015-3769-7
    DOI

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