VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Processing of gelatin-based cryogels with improved thermo-mechanical resistance, pore size gradient and high potential for sustainable protein-drug release
    Gorgieva, Selestina ; Kokol, Vanja
    Porous gelatin (GEL) cryogels were processed by spatiotemporal and temperature-controlled gelation and freezing-lyophilizaton process, followed by zero-length cross-linking, using different ... molarities of reagents (EDC and NHS) and reaction media (100% PBS or 20/80% PBS/EtOH mixture) for variable time extensions (1-24 h). In this way, tuneable cryogels with gradient micro-porosity (from 100 um to1000 um) were formed, being mainly influenced by cross-linkers concentration and EtOH addition. Later affect the pore morphology (from round to ellipsoid), consequently modulating the stead- state physiological swelling profile towards twice lower values (~ 600%) comparing to step-vice swelling of in 100% PBS-media cross-linked cryogels. Whilst the presence of EtOH decelerate the cross-linking kinetic by retaining cryogels micro-structure formed during freezing, the 100% PBS and higher EDC molarity resulted in ~40% cross-linking degree, being expressed as a thermal resistance of cryogels up to ~73 °C. Finally, the tuneable enzymatic resistance allow time-dependent poly-L-Lysine (pL) release profile in up to month period. The processed GEL cryogels have potential in broad range biomedical applications, especially as sustainable, protein-based-drug delivery systems.
    Vir: Journal of biomedical materials research. Part A. - ISSN 1549-3296 (Vol. 103, issue 3, 2015, str. 1119-1130)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2015
    Jezik - angleški
    COBISS.SI-ID - 17920790
    DOI

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