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  • Acute fatty liver of pregnancy - an underlying condition for herpes simplex type 2 fulminant hepatitis necessitating liver transplantation = Akute Fettleber in der Schwangerschaft - prädisponierende Erkrankung für eine fulminate Herpes simplex Typ 2 Hepatitis
    Luzar, Boštjan ...
    The infrequent occurrence of herpes simplex virus (HSV) hepatitis in healthy women in comparison with the high prevalence of HSV infections suggests that, in addition to deranged immunity, an ... underlying condition in the liver might be necessary to develop HSV hepatitis. We report the case of a 28-year-old pregnant woman in the 28th week of gestation. Following HSV type 2 infection of the uterine cervix, acute liver failure developed, necessitating urgent liver transplantation. In addition to fulminant HSV type 2 hepatitis, the explanted liver also showed the histological features of acute fatty liver of pregnancy. The presented case suggests a possible pathogenetic role of acute fatty liver of pregnancy in the development of fulminant HSV hepatitis following recurrent infection with HSV in healthy pregnant women. We believe that early histopathological diagnosis, followed by specific antiviral treatment and liver transplantation in selected patients may improve the clinical outcome of otherwise almost uniformly fatal HSV hepatitis.
    Vir: Zeitschrift für Gastroenterologie. - ISSN 0044-2771 (Letn. 43, 2005, str. 451-454)
    Vrsta gradiva - članek, sestavni del
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 19246041

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