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  • Molekularni mehanizmi inzulinske rezistencije, pretilosti i metaboličkog sindroma = Molecular mechanism of insulin resistance, obesity and metabolic syndrome
    Mlinar, Barbara, 1974- ; Marc, Janja ; Pfeifer, Marija
    Insulin resistance is a state of impaired responsiveness to insulin action. The most common underlying cause is central obesity although primary insulin resistance in normal-weight individuals is ... also possible. Excess abdominal adipose tissue has been shown to release increased amounts of tumor necrosis factor Ž and free fatty acids, which directly aff ect insulin signaling, diminish glucose uptake in the muscle, drive exaggerated triglyceride synthesis and induce gluconeogenesis in the liver. Other factors presumed to play a role in insulin resistance are adiponectin (a decrease), leptin, IL-6 and some other adipokines. Common obesity is thought to be of polygenic originwith influence of ĆobesogenicĆ environment, i.e. increased food intake and the lack of physical activity. Todayćs high prevalence of obesity could beexplained by evolutionary pressure for selection of genes promoting fat storage to survive in starvation. Insulin resistance frequently coexists with central obesity, hypertension and dyslipidemia, which have collectively been denoted as metabolic syndrome. These manifestations represent strong risk factors for diabetes mellitus type 2 and cardiovascular disease.
    Vir: Biochemia medica : glasnik Hrvatskoga društva medicinskih biokemičara. - ISSN 1330-0962 (God. 16, br. 1, 2006, str. 8-24)
    Vrsta gradiva - članek, sestavni del
    Leto - 2006
    Jezik - hrvaški, angleški
    COBISS.SI-ID - 1942641

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