VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Synthesis, structure and cell-toxicity of a choline betainate [Elektronski vir]
    Jurko, Lucija ...
    In this work, choline chloride and betaine hydrochloride were condensed into a - to our knowledge - unreported choline betainate (N,N,N-trimethyl-2-oxo-2-(2-(trimethylammonio)ethoxy)ethanaminium ... chloride) using 1,1'-carbonyldiimidazole (CDI) activation of betaine hydrochloride in dimethylsulfoxide. The product and reaction intermediates were isolated, purified by preparative HPLC and analyzed in detail by infrared and nuclear magnetic resonance spectroscopy. The final product has a high cytotoxicity for L929 mouse fibroblasts, and low antibacterial activity against P. Aeruginosa and S. Aureus at concentrations of up to 20 mg/ml. It could potentially further be investigated for similar uses as suxamethonium chloride, a muscle relaxant drug.
    Vir: Social Science Research Network [Elektronski vir]. - ISSN 1556-5068 (23 Jan. 2024, str. [1-16])
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2024
    Jezik - angleški
    COBISS.SI-ID - 195326211

    Povezava(-e):

    https://dx.doi.org/10.2139/ssrn.4703504
    DOI

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