VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
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Synthesis, purification, and cell-toxicity of a choline betainate [Elektronski vir]Jurko, Lucija ...In this work, choline chloride and betaine hydrochloride were condensed into a - to our knowledge - unreported choline betainate (N,N,N-trimethyl-2-oxo-2-(2-(trimethylammonio)ethoxy)ethanaminium ... chloride) using 1,1′-carbonyldiimidazole (CDI) activation of betaine hydrochloride in dimethylsulfoxide. The product and reaction intermediates were isolated, purified by preparative HPLC and analyzed in detail by infrared and nuclear magnetic resonance spectroscopy. The final product has a high cytotoxicity for L929 mouse fibroblasts, and low antibacterial activity against P. Aeruginosa and S. Aureus at concentrations of up to 20 mg/ml. It could potentially further be investigated for similar uses as suxamethonium chloride, a muscle relaxant drug.Vir: Journal of molecular structure [Elektronski vir]. - ISSN 1872-8014 (Vol. 1312, [art. no.] 138581, Sept. 2024, str. 1-8)Vrsta gradiva - e-članek ; neleposlovje za odrasleLeto - 2024Jezik - angleškiCOBISS.SI-ID - 195589379
Digitalne vsebine: dCOBISS
| Avtor | Jurko, Lucija ... |
| Naslov | Synthesis, purification, and cell-toxicity of a choline betainate [Elektronski vir] |
| Datum objave | 2024-09-15 |
| COBISS.SI-ID | 195589379 |
| Verzija objave v repozitoriju | Založnikova različica |
| Licenca objave v repozitoriju | Creative Commons Priznanje avtorstva 4.0 Mednarodna |
| Embargo | Takojšnja javna objava |
Projekti in financerji, navedeni v objavi
| Naziv | Akronim | Številka projekta | Financer |
|---|---|---|---|
| A Training Network on Designing Novel Bio-based Fibre Products for Targeted Advanced Properties and New Applications | FibreNet | 764713 |
European Commission |
| Ekotoksiologija, toksikološka genomika in karcinogeneza | P1-0245-2019 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Datoteke, ki spadajo k objavi
https://doi.org/10.1016/j.molstruc.2024.138581
Vir: Osebne bibliografije
in: SICRIS
