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  • Molecular basis of lung cancer histogenesis = Molekularna osnova histogeneze pljučnega raka
    Rott, Tomaž ...
    The carcinogenesis of lung cancer is a multi-step process similar to those found in other organic systems. Accumulation of genetic changes is associated with histological-phenotypic changes, from ... normal tissue through precancerouslesions (metaplasia,dysplasia), to iniraepithelial and invasive cancer. Carcinogenesis is essentially a disease of cell cycle. In normal cell,molecular mechanisms of the cell cycle are balanced and self-controlled. The dominant growth-promoting oncogenes, the recessive growth-inhibiting tumour-suppressor genes, genes that regulate programmed cell death (apoptosis), genes involved in DNA repair, and telomerase are the most important molecular systems implicated in carcinogenesis. Exogenous factors can cause gradual accumulation of their molecular changes, with consecutive activation of dominant proto-oncogenes (e.g. KRAS, HRAS, MYC) and silencing ofrecessive tumour-suppressor genes, which are involved in growth suppression and promotion of apoptosis (e.g. P53, RB, BAX). Cells with mutations in oncogenes and tumour-suppressor genes multiply without any restriction and express phenotypic changes from precancerous lesions to invasive carcinoma, corresponding to the amount of molecular changes.
    Vir: Molekularna diagnostika v medicini : zbornik predavanj = Molecular diagnostics in medicine : proceedings (Str. 167-176)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2005
    Jezik - angleški
    COBISS.SI-ID - 20019417

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