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  • Genome-wide DNA methylation analysis of CBCVd-infected hop plants (Humulus lupulus var. “Celeia”) provides novel insights into viroid pathogenesis [Elektronski vir]
    Sečnik, Andrej ...
    Viroids are small, naked, infectious single-stranded RNA molecules that exploit host factors to replicate. Some viroids have been linked to severe diseases in agricultural crops, including the recent ... outbreak of Cocadviroid rimocitri, previously known as Citrus bark cracking viroid (CBCVd), in hop plants (Humulus lupulus). Numerous studies have demonstrated the involvement of viroid-derived RNA in viroid pathogenesis through interactions with RNAi host factors, leading to alterations in gene expression, metabolism, and phenotype. Recent research efforts have also focused on elucidating viroid-induced changes in DNA methylation patterns via the RNA-directed DNA methylation pathway. In this study, we conducted an epigenome analysis of CBCVd-infected hop plants to provide novel evidence supporting the putative role of DNA methylation in CBCVd viroid pathogenesis. Our findings revealed that several genes involved in pathogen interaction pathways, such as MAPK signaling and LRR, exhibit hypomethylation, suggesting that their increased transcription enhances the host’s ability to counteract the pathogen. Intriguingly, genes associated with RNA transcription and encoding key proteins, such as POL II, POL IV, and POL V, display hypermethylation, highlighting the significance of DNA methylation as a defense mechanism.
    Vir: Microbiology spectrum [Elektronski vir]. - ISSN 2165-0497 (Vol. 13, issue 6, [article no.] 0039424, Jun. 2025, 20 str.)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2025
    Jezik - angleški
    COBISS.SI-ID - 233105155

    Povezava(-e):

    https://journals.asm.org/doi/10.1128/spectrum.00394-24
    DOI

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