VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Maternal administration of probiotics augments IL17-committed γδ T cells in the newborn lung
    Tafesse, Yohannes ...
    The early life period is increasingly being recognized as a window of opportunity to shape immunity, where microbiota and related probiotics have an important impact. Innate γδ T cells are the first ... T cells generated in utero, populating epithelial tissues such as the lung and contributing to tissue protection through, for example, IL17 production. Here, we studied the influence of maternal microbiota and probiotic supplementation during pregnancy on innate γδ T cells in the lung and thymus of newborn mice. Detailed time-kinetic experiments showed that at birth, the murine lung T cell population was specifically dominated by IL17-committed γδ T cells expressing an invariant Vγ6Vδ1 TCR. Single-cell RNA-sequencing showed that the biased IL17-commitmentof perinatal lung γδT cells is highly conserved between mice and humans. While maternal microbiota depletion with antibiotics tended to decrease the frequency of the lung Vγ6 T cells of the offspring at birth, the maternal administration of Lacticaseibacillus rhamnosus (L.rhm.), but not of Bifidobacterium animalis subsp. lactis (B.lac.), increased significantly their frequency, resulting in the augmentation of the IL17-commitment of the mouse lung T cell compartment. Altogether, our data indicate that the maternalmicrobiota contributes to the shaping of IL17-committed γδT cells in the lungs of newborns and that maternal administration ofspecific probiotic strains can enhance this process.
    Vir: European Journal of Immunology. - ISSN 0014-2980 (Vol. 55, issue 4, [article no.] e202451051, 2025, str. 1-12)
    Vrsta gradiva - članek, sestavni del
    Leto - 2025
    Jezik - angleški
    COBISS.SI-ID - 234426883

    Povezava(-e):

    https://onlinelibrary.wiley.com/doi/10.1002/eji.202451051
    DOI

vir: European Journal of Immunology. - ISSN 0014-2980 (Vol. 55, issue 4, [article no.] e202451051, 2025, str. 1-12)
loading ...
loading ...
loading ...

Vnos na polico