VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Sex-related differences in recovery of cutaneous nociception after end-to-side nerve repair in the rat
    Kovačič, Uroš, medicina, 1975- ; Sketelj, Janez ; Bajrović, Fajko
    Sex-related differences in the recovery of cutaneous nociception after end-to-side nerve repair were examined in rats. Recovery of nociception in thedorsal foot was determined by skin pinch test 19 ... weeks after the proximal end of the distal stump of the transected peroneal nerve was sutured to the side of the adjacent intact sural nerve (end-to-side nerve coaptation). Axon sprouts in the recipient peroneal nerve were counted by light and electron microscopy. Recovery of nociception due to axon sprouting through the end-to-side coaptation was found in 87% of females and in 60% of males. The area of nociception was not significantly different (P=0.59) between females and males (13+/-8% and 11+/-9%, respectively). The number of myelinated axonsin the recipient peroneal nerve (but not of unmyelinated axons) was significantly larger (P=0.028) in females (median=512, 25th and 75th percentiles: 467 and 594) than in males (median=322, 25th and 75th percentiles: 239 and 468). The majority of these axons in females and males were thin fibres, and recipient nerves in both groups were responsive to nervepinch test. In conclusion, collateral sprouting of thin myelinated nociceptive axons into the end-to-side coapted nerve is more abundant in female than in male rats. However, recovery of cutaneous mechano-nociception due to sprouting of these axons was not different between the two sexes. Possible reasons are discussed.
    Vir: Journal of plastic, reconstructive & aesthetic surgery. - ISSN 1748-6815 (Letn. 62, št. 6, 2009, str. 806-813)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 24140761
    DOI

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