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  • Lysogenic control of Bacillus subtilis morphology and fitness by Spbetavirus phi3T [Elektronski vir]
    Floccari, Valentina Andrea ...
    In lysogenic conversion, temperate phages can profoundly alter the phenotypes of their bacterial hosts. When studying the effects of SPbeta-like viruses on a Bacillus subtilis soil isolate, we ... observed that phage phi3T induced a stable and heritable acquisition of a spherical cell morphology, departing from the typical rod shape of its ancestor. Although time-lapse imaging revealed that the lysogen retained cell wall integrity and symmetric division, it exhibited reduced fitness and increased susceptibility to cell wall-targeting antimicrobials. Remarkably, when SPβ, a homologous SPbeta-like virus, was present, the host retained its rod-shaped morphology despite phi3T superinfection. This study uncovers a novel example of lysogenic conversion in which phage integration into the bacterial genome induces heritable changes in host biology. Additionally, we revealed intriguing phage-phage interactions during polylysogeny that may benefit the host. These findings offer insight into the persistence and absence of specific Spbetavirus variants in natural B. subtilis populations.
    Vir: Communications biology [Elektronski vir]. - ISSN 2399-3642 (Vol. 8, [article no.] 1238, 2025, str. 1-17)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2025
    Jezik - angleški
    COBISS.SI-ID - 246629635

    Povezava(-e):

    https://www.nature.com/articles/s42003-025-08672-x
    DOI

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