VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • T lymphocyte activation and cytokine expression in periapical granulomas and radicular cysts
    Ihan Hren, Nataša, 1962- ; Ihan, Alojz
    Introduction: Radicular cysts (RCs) are periapical lesions resulting in jaw bone destruction. The inflammatory dental periapical granuloma (PG) is considered to be the origin of RC formation; however ... the mechanism of RC development remains unclear. METHODS: Cell suspension from the surgically extirpated tissue of 27 RCs and 25 PGs was obtained. Bacteriological analysis of the PG tissue samples was performed in order to define two major groups of PG according to the prevailing causative bacterial infection: the streptococcal PG (PG-S, n=10) and the anaerobe PG (PG-A, n=9) group. The inflammatory response of tissue infiltrating lymphocytes was assessed by following T lymphocyte activation (HLA-DR expression) as well as interferon gamma (IFN-gamma) and interleukin 4 (IL-4) production which were evaluated by the flow cytometry. Results: In comparison to RC both types of PG contained ahigher proportion of activated T cells (HLA-DR) and lower proportion of IL-4 producing cells. PG-A tissue contained increased percentage of CD3 cells and increased percentage of T helper 1 (Th1) cells in comparison with PG-S. In RC the IFN-gamma production is higher than in streptococcal PG-S but similar as in PG-A. Discussion: Tissue infiltration by Th2 cells and IL-4 production is likely to play an etiopathogenic role in RC formation.
    Vir: Archives of oral biology. - ISSN 0003-9969 (Letn. 54, 2009, str. 156-161)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 25156569
    DOI

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