VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • The impact of national policies on reimbursement of disease-modifying therapies for multiple sclerosis on disease outcomes [Elektronski vir] : Slovenia versus Croatia
    Brecl Jakob, Gregor ...
    Objectives: To assess how national policies on reimbursement for disease-modifying therapies (DMT) for multiple sclerosis (MS) affect disease outcomes. Methods: The study included consecutive ... Slovenian and Croatian people with MS (pwMS) from the MSBase registry. We calculated the following DMT variables: time to first DMT, total DMT duration, and whether DMT was ever used. We used 1:1 propensity score matching to pair pwMS from Slovenia and Croatia to reduce baseline differences between the groups. Results: Out of 894 pwMS from Slovenia and 1363 from Croatia, 565 pwMS from both countries were enrolled after propensity score matching. pwMS living in Croatia had significantly higher disability levels measured by EDSS compared to those living in Slovenia (2.0 vs 1.5, respectively; p = 0.004). The time to first-ever DMT was longer in the Croatian cohort (2.76; 1.20-6.92) than in the Slovenian cohort (1.29; 0.48-4.60), p < 0.001. In a multivariable logistic regression, pwMS residing in Croatia had a 52.8 % higher probability of EDSS ≥3 (Exp(B) 1.528; 95 % CI 1.182-1.974; p = 0.001). Additionally, the time to first-ever DMT increased the likelihood of EDSS ≥3 by 10.6 % (Exp(B) 1.106; 95 % CI 1.083-1.129; p < 0.001). Conclusion: This study demonstrates that national policies on DMT reimbursement influence disability outcomes in pwMS. Those living in countries with less restrictive reimbursement policies are more likely to have lower disability levels.
    Vir: Multiple sclerosis and related disorders [Elektronski vir]. - ISSN 2211-0356 (Vol. 104, [article no.] 106763, 2025, str. 1-6)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2025
    Jezik - angleški
    COBISS.SI-ID - 253205251

    Povezava(-e):

    https://www.msard-journal.com/article/S2211-0348(25)00505-X/abstract
    DOI

Vnos na polico