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  • Neural regulation of acetylcholinesterase-associated collagen Q in rat skeletal muscles
    Trinkaus, Miha ...
    Acetylcholinesterase-associated collagen Q is expressed also outside of neuromuscular junctions in the slow soleus muscle, but not in fast muscles. Weexamined the nerve dependence of muscle collagen ... Q expression and mechanismsresponsible for these differences. Denervation decreased extrajunctional collagen Q mRNA levels in the soleus muscles and junctional levels in fast sternomastoid muscles to about one third. Cross-innervation of denervated soleus muscles by a fast muscle nerve, or electrical stimulation by'fast' impulse pattern, reduced their extrajunctional collagen Q mRNA levelsby 70-80%. In contrast, stimulation of fast muscles by 'slow' impulse pattern had no effect on collagen Q expression. Calcineurin inhibitors tacrolimus and cyclosporin A decreased collagen Q mRNA levels in the soleus muscles to about 35%, but did not affect collagen Q expression in denervated soleus muscles or the junctional expression in fast muscles. Therefore, high extrajunctional expression of collagen Q in the soleus muscle is maintained byits tonic nerve-induced activation pattern via the activated Ca(2+)-calcineurin signaling pathway. The extrajunctional collagen Q expression in fast muscles is independent of muscle activation pattern and seems irreversibly suppressed. The junctional expression of collagen Q in fast muscles is partly nerve-dependent, but does not encompass the Ca(2+)-calcineurin signaling pathway.
    Vir: Journal of neurochemistry. - ISSN 0022-3042 (Letn. 105, 2008, str. 2535-2544)
    Vrsta gradiva - članek, sestavni del
    Leto - 2008
    Jezik - angleški
    COBISS.SI-ID - 25793753
    DOI

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