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  • The PECAM-1 gene polymorphism - a genetic marker of myocardial infarction
    Reschner, Hrvoje ; Milutinović Živin, Aleksandra, 1969- ; Petrovič, Danijel, 1963-
    We investigated a possible association between the C373G (Leu125VaD polymorphism in the platelet endothelial celi adhesion molecule-1 (PECAM-l) and myocardial infarction (MI) among patients with type ... 2 diabetes (T20M) in the Slovene population (Caucasians). The study population of this cross-sectional analysis consisted of 452 subjects with T20M lasting more than10 years: 142 patients with MI (MI group) and 310 patients (control group)with no history of coronary diseases. There were significant differencesof PECAM-1 genotype distribution in patients with MI (CC=28.2%, CG=47.2% and GG=24.6%) compared with subjects in the control group (CC= 17.1 %, CG=53.5% and GG=29.4%). The muitivariate model showed that the CC genotype of the PECAM-1 gene polymorphism (C373G) (OR=1.9, 95% CI 1.2-3.0, P=0.007) wasan independent risk factor for MI. The C allele frequency was also significantly higher (P=0.oD5) in MI (51.8%) than in control subjects (41 %). In addition, our study revealed the connection between smoking habits, the duration of diabetes and the total and LOL cholesterol serum levels and MI in Slovene T20M patients.We suggest that the tested polymorphism of PECAM-l (C373G) is associated with MI. Therefore, it might be used as genetic marker of MI in T20M.
    Vir: Central European journal of biology. - ISSN 1895-104X (Letn. 4, št. 4, 2009, str. 515-520)
    Vrsta gradiva - članek, sestavni del
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 26182105
    DOI

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