VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • 'Bad guys' among the antiparkinsonian drugs
    Pirtošek, Zvezdan, 1956-
    The first effective drugs for Parkinson's disease (PD) were anticholinergics, introduced at the end of 19.th century by Charcot. Since the introduction of levodopa in the sixties of the previous ... century, many new drugs have emerged for the treatment of Parkinson's disease: dopamine agonists (ergot as well asnon-ergot, bromocriptine, pergolide, mirapexine, ropinirole), MAO B inhibitors (selegiline, rasagiline), amantadine, COMT inhibitors (entacapone, tolcapone). In all stages of the disease, levodopa remains the most effective drug for improving motor symptoms in PD. However, long term treatment with levodopa is accompanied by the development of motor fluctuations, dyskinesia, cognitive and neuropsychiatric adverse effects and increasingly diverse spectrum of drugs is needed to alleviate motor and nonmotor symptoms. Some of these drugs have caused considerable concern and controversies and were regarded at certain points as the 'bad guys' of Parkinson's disease pharmacological armamentarium. In the article, a short review of 'bad guys' including anticholinergics, selegiline, tolcapone and dopamine agonists, is given.
    Vir: 1st Croatian Congress on Side Effects of Psychotropics with international participants : Some Selected Papers and Abstracts, February 26th - March 1st 2009, Osijek, Croatia (str. 114-118)
    Vrsta gradiva - prispevek na konferenci
    Leto - 2009
    Jezik - angleški
    COBISS.SI-ID - 26254553

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