VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • The impact of chemical reactivity on the quality and stability of RNA–LNP pharmaceuticals [Elektronski vir]
    Kovačič, Tristan ...
    Lipid nanoparticles (LNPs) are the most established platform for delivery of mRNA payloads. Their tunability and streamlined manufacturing facilitated an unprecedentedly rapid scale-up during the ... COVID-19 pandemic. However, being multicomponent, complex systems also poses a challenge of controlling their quality and safety. Analytical checkpoints need to be established to characterize LNPs on multiple levels during development and commercialization. This Perspective centres on the chemical reactivity and purity of mRNA–LNP components, which need to be addressed as raw materials, drug substance, excipients, and the fully formed and stored product. Herein, we describe such appropriate orthogonal analytics to design and analyse LNP formulations. For such novel biopharmaceuticals, better controls that go beyond the current analytical workflow and address the nuanced chemical stability, which helps ensure reproducibility, stability and safety, need to be established.
    Vir: Nature reviews. Chemistry [Elektronski vir]. - ISSN 2397-3358 (Vol. 9, 2025, str. 790-802)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2025
    Jezik - angleški
    COBISS.SI-ID - 262880003
    DOI

Vnos na polico