VSE knjižnice (vzajemna bibliografsko-kataložna baza podatkov COBIB.SI)
  • Impairment of the vasodilatation capability of the brachial artery in patients with idiopathic venous thrombosis
    Ježovnik, Mateja, 1979- ; Poredoš, Pavel ; Štalc, Monika
    Aim: Determination of the functional capability of the peripheral arteries is increasingly used as an early marker of vessel disease. The aim of this study was to evaluate flow-mediated (FMD) and ... glyceryl trinitrate-mediated (NMD) dilation of the brachial artery in patients with idiopathic venous thrombosis (VT).Methods: Flow-mediated brachial artery dilatation and the dilatation response to glyceryl trinitrate were measured using high-resolution ultrasoundin 97 subjects (49 eligible patients of both sexes, mean age 51.5+/-14.6 years, with idiopathic venous thrombosis, and 48 age-matched healthy controls).Results: Compared to the control group, FMD was significantly reduced in the group of patients with idiopathic venous thrombosis -4.9% (95% CI 1.1-8.7%) vs. 12.7% (95% CI 7.8-17.6%), p<0.001. Patients also had diminished NMD of the brachial artery -12.5% (95% CI 6.6-18.4%) vs. 18.5% (95% CI 10.1-26.9%), p<0.001. In patients, significantly higher levels of circulatory markers (P-selectin, von Willebrand factor) of endothelial dysfunction were registered.Conclusions: Idiopathic venous thrombosis is associated with impaired flow- and GTN-mediated vasodilatory response of the brachial artery. This may suggest involvement of the functional deterioration of the vessel wall in the pathogenesis of idiopathic VT and indicate a relationship between VT and atherothrombosis.
    Vir: Journal of atherosclerosis and thrombosis. - ISSN 1340-3478 (Letn. 17, št. 11, 2010, str. 1190-1198)
    Vrsta gradiva - članek, sestavni del
    Leto - 2010
    Jezik - angleški
    COBISS.SI-ID - 27716569

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