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  • Associations among different functional and structural arterial wall properties and their relations to traditional cardiovascular risk factors in healthy subjects [Elektronski vir] : a cross-sectional study
    Lunder, Mojca, dr. med. ...
    Background: The arterial wall possesses several functional and structural properties that define arterial health. Once they become impaired, cardiovascular risk increases. We aimed to ascertain the ... pattern of correlations among different arterial wall properties and to explore their relations to traditional risk factors and cardiovascular risk stratification. To allow such an investigation a middle-aged healthy population was recruited.Methods: This cross-sectional study included 100 healthy males (aged41.9 +/- 6.4 years). Pulse wave velocity (PWV), beta-stiffness and intima-media thickness (IMT) of the carotid artery, and brachial artery flow-mediated dilation (FMD) were measured by a standardized ultrasound approach. Results: No correlation between FMD and IMT was found; only relatively poor correlations between PWV (or beta-stiffness) and FMD existed,as well as between PWV (or beta-stiffness) and IMT. PWV and beta-stiffness highly correlated. Unexpectedly, only weak associations betweenPWV, beta-stiffness, FMD, IMT and traditional risk factors were revealed. Hence, traditional risk factors (mainly age) explained only 10-50% of variability for PWV, beta-stiffness, FMD and IMT. Although the subjects hadlow cardiovascular risk according to their Framingham score, their arterialwall properties were already impaired, particularly FMD. Conclusion: In healthy middle-age males we found: i) absent or poor correlations among arterial stiffness, IMT and endothelial function; ii) a low impact of traditional risk factors on the studied variables, and iii) the presence of impaired arterial wall properties despite low calculated cardiovascular risk. These results provide a deepened understanding of arterial wall properties andcould help to improve cardiovascular risk stratification.
    Vir: BMC cardiovascular disorders [Elektronski vir]. - ISSN 1471-2261 (Vol. 12, 2012, str. [1-8], 29)
    Vrsta gradiva - e-članek
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 30085849

    Povezava(-e):

    http://www.biomedcentral.com/1471-2261/12/29/abstract
    DOI

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