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  • A low-dose atorvastatin and losartan combination directly improves aortic ring relaxation and diminishes ischaemic-reperfusion injury in isolated rat hearts
    Lunder, Mojca, dr. med. ...
    Background: The cardiovascular pleiotropic effects of statins and angiotensin receptor blockers (ARBs) could be of interest for innovative preventive approaches. We aimed to investigate whether ... low-dose atorvastatin and losartan, separately not possessing protective cardiovascular pleiotropic effects, express them when combined.<br /> Material/Methods: Forty-five adultmale Wistar rats were anaesthetized and their thoracic aortas and hearts were isolated. Relaxation of aortic rings, coronary flow rate and the extent of myocardial ischaemic-reperfusion injury were measured. Different concentrations (0.01, 0.1, 1.0 microM) of atorvastatin and losartan added to a perfusion medium were first tested. The separate drugs, which were ineffective, were then combined at the same concentrations and the concentration was tested in the same model.<br /> Results: Low concentrations of atorvastatin or losartan (0.1 and 1 microM, respectively) produced no effects in isolated aorta. However, surprisingly, when these drug concentrations were combined, a significantly improved endothelium-dependent relaxation of the thoracic aorta was observed. Similarly, when combining individually ineffective concentrations of atorvastatin or losartan (0.01 and 0.1 microM, respectively), significantly increased coronary flow and a decreased extent of myocardial injury were observed. By using a nitric oxide-synthase inhibitor, we demonstrated that the vasodilatory effects obtained were nitric oxide-dependent. The degree of effectiveness by the combination was comparable to that obtained by 10-fold (atorvastatin) or 100-fold (losartan) higher concentrations of the separate drugs.<br /> Conclusions: Our results revealed that remarkable additive/synergistic effectsexist between low-doses of a statin (atorvastatin) and an ARB (losartan), resulting in important cardiovascular protection. This new conceptcould be valuable in cardiovascular prevention.<br />
    Vir: Medical Science Monitor. - ISSN 1234-1010 (Vol. 18, iss. 9, 2012, str. BR366-BR374)
    Vrsta gradiva - članek, sestavni del
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 30127577

    Povezava(-e):

    http://www.medscimonit.com/index.php?/archives/article/883347

vir: Medical Science Monitor. - ISSN 1234-1010 (Vol. 18, iss. 9, 2012, str. BR366-BR374)
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