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  • Association of manganese superoxide dismutase and glutathione S-transferases genotypes with myocardial infarction in patients with type 2 diabetes mellitus
    Kariž, Stojan ; Nikolajević, Jovana ; Petrovič, Danijel, 1963-
    Aim: In the present study we investigated the association between genetic polymorphisms with functional effects on redox regulation: Val16Ala of manganese superoxide dismutase (MnSOD), polymorphic ... deletions of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and Ile105Val of glutathione S-transferase P1 (GSTP1) and myocardial infarction (MI) in a group of patientswith type 2 diabetes mellitus. Methods: The study population consistedof 463 Caucasian subjects with type 2 diabetes mellitus of more than10 years' duration: 206 patients with MI and 257 patients with no history of coronary artery disease (CAD). Genotypes were determined by polymerase chain reaction (PCR) with restriction fragment length polymorphism (RFLP) and with multiplex PCR. Results: The genotype distributions of tested single nucleotide polymorphisms did not show significant difference between cases andcontrols. After adjustment for age, gender, smoking, BMI, duration of diabetes and lipid parameters carriers of GSTM1/GSTT1-null haplotype showed an increased risk for MI (OR=3.22, 95% CI 1.37-5.04, p=0.03). Conclusion: The GSTM1/GSTT1 haplotype might be a genetic risk factor for MI in patients with type 2 diabetes mellitus.
    Vir: Diabetes research and clinical practice. - ISSN 0168-8227 (Vol. 98, iss. 1, 2012, str. 144-150)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2012
    Jezik - angleški
    COBISS.SI-ID - 30200281
    DOI

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