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  • GSTM1-null and GSTT1-null genotypes are associated with essential arterial hypertension in patients with type 2 diabetes
    Petrovič, Danijel, 1963- ; Peterlin, Borut, 1963-
    Objective To evaluate whether the genetic polymorphisms of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1), Ile105Val of the GSTP1 (rs947894), and the Val16Ala polymorphism of the MnSOD (rs4880) ... are associated with essential arterial hypertension (EAH) in Caucasians with type 2 diabetes. Design and methods 1015 Slovenian subjects (Caucasians) with type 2 diabetes with/without EAH were enrolled in the cross-sectional study. Genotypes were determined by multiplex PCR amplification and PCR-restriction fragment length polymorphism method. Results In the cross-sectional study, GSTM1-null genotype and GSTT1-null genotype were associated with EAH in subjects with type 2 diabetes (59.0% vs. 50.3%, p = 0.007; 28.5% vs. 20.7%, p = 0.008; consequently). Conclusion After adjustment for age, body mass index, and hsCRP level, GSTM1-null and GSTT1-null genotypes were found to be independent risk factors for the development of EAH in Slovenian patients with type 2 diabetes.
    Vir: Clinical biochemistry. - ISSN 0009-9120 (Vol. 47, iss. 7/8, May 2014, str. 574-577)
    Vrsta gradiva - članek, sestavni del
    Leto - 2014
    Jezik - angleški
    COBISS.SI-ID - 31248601

    Povezava(-e):

    http://www.sciencedirect.com/science/article/pii/S0009912014001258
    DOI

vir: Clinical biochemistry. - ISSN 0009-9120 (Vol. 47, iss. 7/8, May 2014, str. 574-577)
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